Severe aggression in rats induced by mescaline
but not other hallucinogens

Sbordone RJ, Wingard JA, Gorelick DA, Elliott ML.
Psychopharmacology (Berl). 1979;66(3):275-80


Pairs of male Sprague-Dawley rats were administered mescaline, lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), 3,4-dimethoxyphenylethylamine (DMPEA), or 5-hydroxydopamine (5-OHDA) IP prior to being placed in a shock-elicited aggression situation. When foot shock was delivered, controls struck each other with their forepaws, but never engaged in either biting or injurious fighting. Mescaline-treated rats (50 or 250 mg) rarely struck each other, but engaged in nearly lethal biting. While LSD (25--400 micrograms/kg), psilocin (2.0 mg/kg), and DMT (5 mg/kg) produced some biting, this did not significantly differ from controls and never resulted in injuries. At higher doses, psilocin, DMT, and DMPEA decreased the amount and intensity of fighting. Rats treated with 5-OHDA (8--200 mg/kg) or LSD (25--400 micrograms/kg) did not differ from controls. These results suggest that mescaline's ability to induce pathological aggression in rats exposed to foot shock is not shared by other hallucinogens or nonhallucinogenic mescaline analogues.

Peyote use during pregnancy
3,4,5-Trimethoxybenzoic acid
Dihydrobenzofuran analogues
Mescaline and prolactin secretion
Mescaline: synthesis (from PIHKAL)
Mescaline-induced rodent aggression
The Peyote Way and Culture Care theory
The Doors of Perception by Aldous Huxley

Future Opioids
BLTC Research
Wirehead Hedonism
Utopian Pharmacology
The Hedonistic Imperative Go to Good Drug Guide
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family